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​​​​© 2018 pMedGR Project Management

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UNITS

Next generation sequencing technologies and advanced mass spectrometry platforms coupled with advanced imaging facilities, set the basis for personalized and stratified drug discovery and development. The following coreunits will be established in the context of pMedGR, to address the needs of both the industrial and academic sector in implementing personalized medicine.
Personalised Genomics & Transcriptomics Unit

 

The Unit will provide services and support in high-throughput, genome wide research, including genomic applications (whole genome sequencing, exome sequencing, whole genome mapping, genotyping etc), transcriptomic (RNA-Seq, smallRNA-Seq), epigenomic (MeDIP-Seq, ChIP-Seq, bisulfide sequencing etc), metagenomic and genotyping services. 

Proteomics and Metabolomics Unit

 

The Unit will provide the following services:

 

  • improved sample separation and sensitivity

 

  • accurate quantization in parallel with identification

 

  • high-throughput analysis of proteins and metabolites

 

  • metabolic profiling and fingerprinting ​

Mass Cytometry (CyTOF) Unit

 

Using the 3rd generation Helios cytometer, allows the simultaneous identification of over 150 different parameters at a single cell level, leading to the discovery of new cell types and biomarkers valuable in disease diagnosis, response to therapy and treatment​. 

Single Cell Analysis Unit

 

Single Cell Analysis is an innovative technology that allows the evaluation of the genetic profile at a single cell level within a tissue, leading to the identification of specific biomarkers and the development of specialised diagnostic and therapeutic approaches. 

Data Analysis, Integration and Modeling Unit

 

The Unit will provide bioinformatic and data analysis resources for individual medical genomic applications through the following pipelines:

 

  • Analysis of genetic variability

  • Transcriptome profiling

  • Pharmacogenomic analyses

  • Individual epigenetic profiling

  • Modeling

  • Efficient reference genome indexing

  • ExomeSeq data analysis

Clinical Samples Reception and Processing Unit

 

The Unit will determine strategies and
implement best practices for collecting, cataloguing, and storing samples and specimens (fresh, frozen or FFPE samples) for use in the above advanced technology platforms. 

Cyclotron and PET Imaging Unit

 

The Unit will contribute to:

 

  • Identifying imaging biomarkers

 

  • Visualising molecular processes for early diagnosis

 

  • Identifying pathophysiological alterations when disease is present

 

  • Allowing diagnostic precision as well as treatment monitoring and response

 

  • Combining targeted imaging and therapy (theragnostics) and Individualising, image-guided therapeutic interventions​

Organs-on-Chips 

 

Soon to be included in pMedGR’s technologies.

 

This innovative technology recreates the natural physiology and mechanical forces experienced within the human body, thus providing a new standard for predicting how a human may respond to medicines, chemicals, and foods — with greater precision and control than today’s cell culture or animal-based testing methods.